Medicated For Your Protection
A lot of our information comes from direct personal experience, along with that of our friends, and that of the many people who posted all the incarnations of Crazy Talk: the Crazymeds forum various online support groups, consumer review sites, and the like - what’s known in the trade as anecdotal evidence. I had thought that all sites about meds skewed negative, but this study found that sites run by medical professionals were more neutral-to-positive about meds, so that makes me feel a lot better about the data I’ve gathered from them1. As I also gather data from sites that have nothing to do with medication and medical conditions, I’m pretty confident about both the size and spectrum of any online sampling I do. Most of them are not random sites either, but are targeted based on demographic data I’ve collected since I noticed people with certain brain cooties tend to participate in similar activities or have similar interests, and that some sites about those activities/interests have an off-topic area dedicated to the specific mental health issue (depression, anxiety, etc.), or migraines, epilepsy, whatever. Of course anyone with some other form of brain cooties would post something in that area, but you get the idea. I’d give some examples, but since Big Pharma refuses to buy any ads because I am, in the words of one Big Pharma ad buyer, “too unpredictable,”2 I’m not going to give them any leads to a shitload of potential customers for free.
Just the Facts
We also sit on our asses all day long and do a bunch of research. We find a study that is of interest and we put a link to it or an article about it within the page on the med in question. So there are many specific articles and studies that we’ve referenced throughout this site, either by direct link to the source (when available online) or by quaint footnotes (when we read it in something not available online). However there are a few works that we’ve built upon as a foundation, and that we also reference to check on certain things. This isn’t a static list.
Putting the Mental in “Reading is Fundamental”
Books, Articles, and Other Paperwork
Here are the key books and papers that comprise the foundation of what we know about neuropsychopharmacology. As expensive as it is, I consider paper to be the superior medium. Follow the links for the books to buy them or get more information about them. You’ll also find a lot more books (and other crap) on more subjects at the Crazymeds bookstore.
Honestly, unless you are a professional3, stick with the consumer-grade stuff.
- Stahl, Stephen M. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) Third edition Cambridge University Press 2008. ISBN:978–0521673761
- Julien, Robert M. Ph.D, Claire D. Advokat, and Joseph Comaty Primer of Drug Action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs 12th edition Worth Publishers 2011. ISBN:978–1429233439
- Stahl, Stephen M. The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition Cambridge University Press 2009. ISBN:978–0521743990
- Virani, Adil S., K. Bezchlibnyk-Butler, and J. Jeffries Clinical Handbook of Psychotropic Drugs 18th edition Hogrefe & Huber Publishers 2009. ISBN:978–0889373693
- Silberstein, Stephen D., Michael J. Marmura Essential Neuropharmacology: The Prescriber’s Guide Cambridge University Press 2010. ISBN:978–0521136723
- Stein, Dan, Bernard Lerer, Stephen Stahl Evidence-based Psychopharmacology Cambridge University Press 2005. ISBN:978–0521531887
- Kaufman, David Myland, MD Clinical Neurology for Psychiatrists W.B. Saunders Company 2001 ISBN:1416030743
- Levy, René H., Richard H. Mattson, Brian S. Meldrum, and Emilio PeruccaAntiepileptic Drugs Lippincott Williams & Wilkins 2003. ISBN:0781723213
- Montgomery, Stuart A., Halbreich Uriel Pharmacotherapy for Mood, Anxiety, and Cognitive Disorders American Psychiatric Publishing. 2000 ISBN:0880488859
- Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series) An imprint of Elsevier 2007. ISBN:978–0323040587. The final edition, unfortunately.
- PDR: Physicians’ Desk Reference 2010 64th edition back through to 53rd edition of 1999. Old copies of the PDR come in handy for PI sheets that are no longer available and difficult to find, as well as to track the changes in both indications and adverse effects.
- Paykel, Eugene S., MD FRCPsych Handbook of Affective Disorders Second Edition The Guilford Press 1992 ISBN:0898626749
- Gordon, Hirsch L., MD, Ph.D, FAPA The New Chemotherapy in Mental Illness Philosophical Library 1958
Consumer-oriented books have a lot of good information in them. They’re usually a lot more accurate about side effects than the books doctors read.
- Diamond, Ronald J., MD Instant Psychopharmacology 2nd Edition W.W. Norton 2002. ISBN:978–0393703917
- McManamy, John Living Well with Depression and Bipolar Disorder: What Your Doctor Doesn’t Tell You…That You Need to Know First Edition Collins 2006. ISBN:978–0060897422
- Miklowitz, David J., Ph.D The Bipolar Disorder Survival Guide The Guilford Press 2002.
- Drummond, Edward, MD The Complete Guide to Psychiatric Drugs John Wiley & Sons 2000. ISBN:0471353701
Papers and Articles Used for Background Information on Numerous Pages
These are mainly about pharmacology. Links will take you to the free full-text articles or sections of websites devoted to pharmacology.
- Faught, Edward. “Topiramate in the treatment of partial and generalized epilepsy.” Neuropsychiatric disease and treatment 3.6 (2007): 811-821.
- Ma, Margaret K., Michael H. Woo, and Howard L. Mcleod. “Genetic basis of drug metabolism.” American Journal of Health System Pharmacy 59.21 (2002): 2061-2069.
- Cardoso, Tânia AMO, Fernando Cendes, and Carlos AM Guerreiro. “Is low antiepileptic drug dose effective in long-term seizure-free patients?.” Arquivos de neuro-psiquiatria 61.3A (2003): 566-573.
- Hinz, Marty, Alvin Stein, and Thomas Uncini. “Monoamine depletion by reuptake inhibitors.” Drug, healthcare and patient safety 3 (2011): 69. Marty Hinz; Alvin Stein; Thomas Uncini Drug, Healthcare and Patient Safety, October 2011 - Dove Press
- Olson, Kent R MD, FACEP, Michael A Miller, MD, et al. “Warfarin and Superwarfarin Toxicity” emedicine.medscape.com (2013)
- Lynch, Tom, PharmD, and Amy Price, MD “The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects” Am Fam Physician. 2007 Aug 1;76(3):391-396.
- Le, Jennifer, PharmD, MAS, BCPS-ID “Pharmacokinetics” Merck Manual for Healthcare Professionals Last revised May 2014
- Pharmacorama’s Pharmacokinetics section
Pile of Pills
Medicated For Your Protection
If It’s on the Internet it Must be True?
Know your sources! It should be obvious, but in case it’s not, any site that makes claim about drugs, supplements, therapies, etc. needs to be backed up by cites (references) to quality research material and/or clearly labeled “my personal experience and experience of people I know.” That’s how we do it at Crazymeds, one of the first of a limited number of sites that combines lots of personal experience (anecdotal evidence) and lots of research4.
So if you read an article making vague references, or cites other pages on the same site or elsewhere that are equally full claims with nothing in the way of proof, consider it “for entertainment purposes only.” What you want are sites full of cites, like much, but not all, of Wikipedia, and the articles you’ll find on the sites below.
Even though we, and other people, cite a bunch of stuff, how do you know it’s any good? The best way is to ask someone who reads a lot of this stuff for a living5. If you don’t have access to someone like that, at least I have a Page on Evaluating Research Papers, which shows you how to tell if a paper uses good science or not, and a Page on Rating the Assessment Tests used by the people who write said papers. Scrutinize Crazymeds and every other site that backs up what is written there with references to peer-reviewed journals and the like.
Ready to do some of your own research? Here are the places either we use all the time, or have recently found and will be using all the time.
- Neurotransmitter.net Tons of information and research on psychiatric and neurological conditions, the drugs that treat them, the rating scales used to measure the efficacy of said drugs, and much, much more. All neatly indexed and categorized to make it easy to make sense of a bunch of diverse information. I had no idea how much research was being done on hangovers until I hit this site. I knew doctors liked to party (considering that my stepfather is a vascular surgeon I had a first-hand look at how much doctors liked to party), but who knew they were getting grant money for it? A key site for patients, students and, most importantly, doctors of all stripes, shapes and sizes.
Must-read sections include:
- Drug Reference for FDA Approved Psychiatric Drugs @ Neurotransmitter.net
- The Disorders Research pages, such as the bipolar disorder research index
- Neuroscience Research pages, such as the serotonin research index
- Not only that, Shawn has links to tons of other sites offering free full-text papers including:
- Standford University’s Highwire over 2 million papers available.
- Science magazine’s collections. Of special interest to us - under Life Sciences - are their collections of papers on
- And a bunch of tools to make mining The Literature easier
- Sheldon Preskorn’s Applied Clinical Psychopharmacology www.preskorn.com M.D. Chief Executive Officer of the Clincal Research Institute and a Professor in the Department of Psychiatry and Behavioral Sciences at the University of Kansas School of Medicine - Wichita
- Dr. Preskorn has authored over 300 scientific and professional articles, and many of them are available at this site, which is full of useful psychopharmacological data involving drug-drug interactions, methods of actions, clinical efficacies, pharmacokinetics and more written in a fairly accessible way. Dr. Preskorn has received continuous grant funding since 1978 for studies in the areas of psychopharmacology, neuroscience, and psychiatric illnesses. While most of the articles are at least ten years old, Dr. Preskorn is still publishing papers, so we might be seeing new material eventually. Regardless, he covers the basics of psychopharmacology in a way that makes sense, and the basics haven’t changed much.
Sources of Free Full-Text Articles and Papers
- PubMed Central is the National Institute of Health’s repository of full-text articles and even online books that are available free of charge. These are your tax dollars at work, people, make good use of them. While part of the same library, don’t confuse PubMed Central with its better-know sibling…
- PubMed. With over 14 million citations covering 50 years of research, PubMed is a treasure trove of knowledge. The only problem is most of it costs money to read. If you’ve got the cash or access through a university library, that’s great. Fortunately, you can filter your searches to include only free full-text entries. They aren’t always available for free when they claim to be, but they are far more often than…
- PLoS Medicine. The Public Library of Science is probably the best-known repository of free, peer-reviewed papers and articles.
- Your local hospital. Or not so local hospital. Many hospitals have reading libraries full of journals. While lots of colleges with med schools limit access to students, hospital libraries are usually open to the public.
- Google Scholar. In case you need the URL spelled out for you: scholar.google.com Note the scholar part. Google Scholar has made finding papers both easier and vastly more frustrating.
- Easier because it’s basically regular Google that has filtered out most of the crap that doesn’t meet peer-review specifications.
- More frustrating because it’s Google. Which means…
- it includes all sorts of crap that shouldn’t be there;
- still omits stuff you expect Google to find;
- returns dead links;
- its advanced search, while much improved, still doesn’t come close to PubMed’s sophistication;
- “sophistication” also means “difficulty of use for anyone who hasn’t spent years in the data mines”;
- and lies about papers being free full-text five times as often as PubMed.
- Google Scholar has a huge advantage over PubMed. PubMed usually lists only one place where an article appears.
- Unless a paper has the full-text version available at PubMed Central in addition to the journal in which it was published. That’s generally the only time an abstract in PubMed will
have a link to more than one location for the entire article, free or not.
- Google Scholar lists every place it can find the abstract, full text, and where it was cited. In one handy location.
- Which means if PubMed has a link to the journal in which the article was published, and it costs money to read it, Google might have a link to a journal where, for some reason, it’s free but not pirated.
- Don’t ask me how academic intellectual property rights work. I have no clue.
- So if both Google Scholar and PubMed have pulled the free full-text bait’n’switch8, you still might be able to find some.
- If there is a link for “All (some number) versions”, click on it. That will take you to a page of links (real or imagined) to all versions Google can find.
- Including cites and patents.
- Depending on how badly you want to see an article without paying for it you may as well click on everything. Eventually you’ll get a feel for which sites have free full-text, even when they aren’t listed as having it.
- If there is a link for “All (some number) versions”, click on it. That will take you to a page of links (real or imagined) to all versions Google can find.
Sites with Other Research Material
Not everything useful to know is in the form of a research paper or journal article. These sites are full of great material, both for general knowledge and very specific data.
- The PDSP Ki database All Ki values, all the time. These are the raw numbers used to determine the potency of certain aspects of the freebase form (E.g.: paroxetine, but what is actually in a pill of Paxil is paroxetine HCl; while Tegretol is full of freebase carbamazepine) such as neurotransmitter reuptake inhibition.
I cannot stress this enough: Potency and efficacy are two very different things.
Also: if you don’t know how to use the database, and what all parameters and results mean, you probably shouldn’t be using it in the first place.
- Neuroscience Online, the Open-Access Neuroscience Electronic Textbook From the University of Texas, one of the best places on the planet for the study of psychiatric and neurological conditions. Making this combination text book and lecture series available for free is as awesome as its contents.
- Global RPh - I don’t know if they have everything you need to pass the MCATs and get you through medical school, but it sure seems that way.
- University of Maryland’s Medical Reference Guide “Guide” is an understatement, as it includes a medical encyclopedia, patient education information that people should be reading instead of that crap on WebMD, and what has to be the best Complementary and Alternative Medicine Guide on the planet. Just ignore that truly worthless drug-drug interaction checker.
- WikiDoc Imagine what Wikipedia was supposed to be. Only written by doctors.
- Merck Manuals Because some things never go out of date.
- ChemSpider Close to, maybe even everything you ever wanted to know about the active ingredient in a med. It’s all about the patentable molecules.
- Pharmacorama - drug knowledge. If you’re studying drugs in medical or pharmacy school, or as a writer, think of Pharmacorama as something along the study guide to Cliff’s Notes spectrum. They’re pretty damn close to essential.
This is Your Brain on Candid Camera
Many of the conditions and treatments we deal with often involve specific areas of the brain. Here are some places to help find your way around your head.
- Brain Facts Basic brain stuff.
- Whole Brain Atlas Pretty pictures of brains via neuroimaging.
- Michigan State Human Brain Atlas
- University of Washington’s Brain Atlas For one of the most respected medical schools in the country, having a section on their site that’s a total throwback to 1997 is surprising. So if you want brain pictures while feeling nostalgic, or also wanting to see what teh interwebs looked like 20 years ago, this is the place.
Lists of Even More Sites
Still not satisfied? Can’t I do anything right?
- a big list of neuroscience-related sites.
- Neurosciences on the Internet.
- University of Iowa’s Hardin Library for the Health Sciences list of brain atlases. Because you can never have too many brain pictures.
Medicine Is The Best Medicine
Vaccines Cause Immunity
Brain Cooties Aren’t Contagious
Suicide Is Murder
Tips on Finding and Reading Research Papers
Finding and Reading The Literature is as much of an art as the research itself. Here are a few peer-reviewed tips:
- If you don’t know where to start, Angelo State University’s pamphlet How to recognize peer-reviewed (refereed) journals is extremely basic.
- I keep forgetting everyone who reads this site does not have over a decade’s experience with this crap.
- Just pretend you’re writing a paper for college.
- Trisha Greenhalgh of The BMJ has written several articles about how to read and interpret research papers.
- Once again: the Page on Evaluating Research Papers has a shitload of info on how to tell if the papers you find are any good.
Pictures Worth Millions of Words
To give you an idea of what the Crazymeds library looks like, on the left is the primary Crazymeds library. Note all the journals on the lower shelves. Some of my articles will have references to papers with no links. Now you see why. I don’t like to link to the abstract as I, and other people without subscriptions to online services, will use abstracts alone as source material. I try to avoid that, but sometimes everything I need is in the abstract. So if I read it in a journal and it’s not available online, I don’t link to the abstract. That’s Bes on top of the bookcase. Here’s a little more about Bes.
On the right is a shot of some of the older material I used and most of the old medical texts I’ve collected. Those really battered ones are versions of the PDR from the late 19th century, when everything was just ingredients and all pharmacies were compounding pharmacies. The two small books next to The United States Dispensatory 23rd edition (1943) are formularies from 1904 and 1922. Not a list of meds 100-year-old insurance plans covered, but the actual recipes for treatments of different conditions. What did they give people for mania in 1922? One treatment is a mix of potassium bromide (one of the few working AEDs of its time, and one still used today to treat epilepsy in animals, and people in countries where phenobarbital is reserved for the rich) and a tincture of cannabis (which far too many of the bipolar self-medicate with). I guess things haven’t changed all that much.
You think your side effects are bad today? Some of the bromides make leprosy look good. Little wonder why many epileptics chose the accepted the alternative therapy of the day: bland foods, lukewarm baths, isolation from society, and celibacy9 instead of the available meds. Just like the ketogenic diet it supposedly worked better the younger one began. Now how many monks and nuns had religious visions? That’s Ek Balam, Bes’ sibling, on top of the bookcase.
Blasts from the Past
An aspect of the HONcode Attribution guideline is:
All medical content (page or article) has to have a specific date of creation and a last modification date.
Date of last modification must also be included on every page describing ethical and legal information, author(s), mission, and the intended audience. -- Principle 4 - Information must be documented: Referenced and dated
Since I tend to go overboard on stuff, part of going with a wiki is because you can see the entire editing history of any page. And if that isn’t enough for you, check out The Wayback Machine’s archive of crazymeds.org and crazymeds.us. I don’t think their archive of crazymeds.org is correct, as I’m pretty sure I didn’t have the format for pages on drugs until January 2004, December 2003 at the earliest. My memory is getting really frelled, but I’m fairly certain that the most I’d done by the end of November 2003 was to cut the one huge file into a bunch of smaller ones for each drug or drug class.
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Breakfast of Champions
1 And I feel so…Fox News when a study that uses Crazymeds as a major source of its data proves me wrong.
2 And another ad buyer said he didn't want to get a call from the CEO of J&J if one of their banner ads showed up on Crazymeds. In spite of all the lrrrrv I have for Topamax and Risperdal. That's on page 32 of Beyond Viral by Kevin Nalty. See the page on News, Reviews and Cites for a link, or search Google Books for Crazymeds.
3 Including professional patients.
4 Which is apparent as there are often more cites than the Wikipedia article for the same med.
5 Although most people doing that will usually make the same joke about it not really being a living.
6 Some terminology for beginning researchers. "Free full-text" means all of the text of something that is in a printed journal is available online for free. All of the diagrams, charts, photos, etc. are almost always included these days, but there's no guarantee with older papers. Plus some data aren't included in either when research is carried out using the resources (cash and/or data) of drug companies. Articles and papers are two different things. Papers are the result of original (or 'original') research, articles are everything else. Articles have plenty of value, as they can quote data from recently published research papers that aren't currently available online.
7 I also like reading the journals I get from doctors. So if you don't see a link to the cited source, I read it in an actual magazine printed on paper. Or something approximating paper.
8 It's not their fault. Mostly. Many journals make articles available for free for a limited time, and going back to update that change is a hell of a lot of work. I can also understand why articles are free for just a couple of months. Bandwidth isn't free. The Scientific, Technical & Medical publishing division of Reed-Elsevier managed to clear a profit of only £826,000,000 (about 1.3 billion US dollars) in 2013, without any advertising in their online publications. There's your option, kids. I could charge $15 an article and all your ad-blocking software be useless. Since it's putting publishers like me who offer free content in exchange for ads out of business, it will probably wind up being useless in a couple of
years months weeks in any event.
9 Wait a minute, I'm on a highly restrictive diet, I live on the fringes of civilization, I'll not interact with another person - even over teh interwebs - for weeks at a time, I'll soak in the tub for a couple of hours, and I haven't been laid in… what year is this? W. was still President and the economy hadn't tanked the last time I had any fun, and I haven't been in anything close to a relationship with regular congress since 2004. It's not perfect - if my Topamax levels get hosed by a funky generic sometimes I'll have an aura first thing in the morning or wake up with a seizure hangover - but both my seizure control and bipolar symptoms have been a lot better. Jackson knew his shit.
Crazymeds’ General Bibliography & Guide to Medical Research Sites by Jerod Poore is copyright © 2011 Jerod Poore
|Last modified on Sunday, 20 July, 2014 at 17:24:21 by JerodPoore||Page Author: Jerod Poore||Date created: 31 January 2011|
All drug names are the trademarks of someone else. Look on the appropriate PI sheets or ask Google who the owners are. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of any trademarks may have changed without my noticing.
Page design and explanatory material by Jerod Poore, copyright © 2004 - 2014. All rights reserved.
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Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.
All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Crazymeds is optimized for the browser you’re not using on the platform you wish you had. Between you and me, it all looks a lot cleaner using Safari or Chrome, although more than half of the visitors to this site use either Safari or Internet Explorer, so I’m doing my best to make things look nice for IE as well. I’m using Firefox and running Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!
‘Everything is true, nothing is permitted.’ - Jerod Poore
1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas? I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.