|US brand name: Desyrel|
|Generic name: trazodone|
side effects, dosage, how to take & discontinue, uses, pros & cons, and more
Table of Contents (hide)
- 1. Other brand names & branded generic names1
- 2. Trazodone’s FDA Approved Uses
- 3. Trazodone’s Off-Label Uses
- 4. Trazodone’s pros and cons
- 5. Trazodone’s Side Effects
- 6. Interesting Stuff Your Doctor Probably Won’t Tell You about Trazodone
- 7. Trazodone’s Dosage and How to Take Trazodone
- 8. How Long Trazodone Takes to Work
- 9. How to Stop Taking trazodone
- 10. How Trazodone Works
- 11. Shelf life
- 12. Comments
- 13. Desyrel Ratings, Reviews, & Other Sites of Interest
- 14. References
Other Forms: orange flavored solution
1. Other brand names & branded generic names1
- Azonz (Finland)
- Beneficat (Argentina)
- Bimaran (Argentina)
- Deprax (Spain)
- Depresil (Philippines)
- Depyrel (Israel)
- Desirel (Thailand)
- Mesyrel (Taiwan)
- Manegan (Argentina)
- Molipaxin (United Kingdom; Ireland; South Africa)
- Pragmarel (France)
- Reslin (Japan)
- Taxagon (Argentina)
- Thombran (Germany)
- Trazolan (Belgium; India; Netherlands)
- Trazone (Indonesia; Portugal; Taiwan)
- Trittico (Austria; Colombia; Greece; Hong Kong; Italy; Peru; Switzerland)
- Torazodon (Japan)
- Trittico (Israel)
- Trazodil 100 (Israel)
- レスリン (Japan)
Major depressive disorder, with or without anxiety.
- Sleep Disorders
- Bipolar Depression
- Chronic Fatigue
- Sleep Problems
- Sleep Issues
- Erectile Dysfunction, where it failed. But…
- SSRI-induced sexual dysfunction. Overall the data are mixed, but it’s still worth a shot.
- You’re getting sleepy
- <Yawn> excuse me.
- Irritable Bowel Syndrome
- your eyes are getting heavy
- Eating Disorders
- Are you tired yet?
The antidepressant you need if you have the combination of insomnia combined with mild depression and/or anxiety.
You might just sleep a little too well.
Sleepiness, headache, sleepiness, dizziness, sleepiness, nausea, sleepiness, dry mouth, sleepiness, blurry vision, sleepiness, sweating, sleepiness, insomnia or sleepiness, diarrhea or constipation, and did I mention you’ll be tired? Most everything but the sleepiness and, if you get the, dizziness and blurry vision, will go away within a week or two. The dizziness and blurry vision may take a little longer. If they last too long, talk to your doctor.
Low blood pressure, weight gain. General cardiac weirdness, so trazodone shouldn’t be used if you have a history or family history of heart issues, at least, not without prior clearance from a cardiologist. Since it makes you sleep better, many people report vivid or unusual dreams. Like Seroquel, another medication prescribed for insomnia alone, there’s sometimes a nasty hangover the first few days after using trazodone. It usually goes away in a day or two.
Priapism so bad that surgical intervention was required to get rid of the unending hard-on. Bob Dole shouldn’t have relied on Viagra to take on Bill Clinton, Bob Dole should have tried trazodone to go macho a macho with the president. Wait, there’s more. Not only can men get stuck that way, but women too, as it can cause clitoral priapism. And if that weren’t enough, persistent genital arousal disorder and spontaneous orgasms in an elderly postmenopausal woman.
Trazodone is best taken with food, so take it after dinner, or dessert, to ensure a quality night’s rest.
The major metabolite of trazodone is meta-chlorophenylpiperazine (mCPP), one of the nigh-infinite number of drugs sold as “ecstasy” in the US in the 1990s. Why is beyond me, as it’s a hallucinogen that gives you a migraine2. Unless it was supposed to scare those party kids straight or something like that.
The initial dose is 150mg a night, taken after dinner or “a light snack.” But, really, start at just 50mg if you want to wake up the next morning. If you don’t respond after one week, increase it to 100mg. Unlike SSRIs, people respond to trazodone rather quickly, so you can work up to that 150mg dosage after two weeks, then wait a month before increasing the dosage. After that it’s an increase of 50mg a day every four days or so, dividing the dosage, until you reach the maximum of 400mg a day.
Like Remeron, two weeks for depression, one-to-two nights for sleep.
Your doctor should be recommending that you reduce your dosage by 50–100mg a day every 3–5 days if you need to stop taking trazodone.
Trazodone’s mechanism of action is similar to its chemical cousin nefazodone; they are Serotonin Antagonist and Reuptake Inhibitors (SARIs). Based upon the Communications Interference Hypothesis of psychiatric and neurological conditions (or brain cooties as we often call them), trazodone effectively raises the serotonin levels in your brain by letting your synapses soak in serotonin for longer than usual by slowing (inhibiting) the mechanism of serotonin transmission deeper into the neurons (reuptake). It also an antagonist - it blocks excessive amounts of a neurotransmitter - of serotonin, including any excessive serotonin created by its own reuptake inhibition, at the 5HT2A and 5HT2C receptors, excess norepinephrine at the alpha 1 noradrenergic receptors, and is an antihistamine approaching Zyprexa-level of potency. The first two account for its actions as an antidepressant. Being an 5HT2A and 5HT2C antagonist and literally 100 times more potent than Benadryl is why trazodone knocks you out until next Tuesday.
Trazodone is the official antidepressant of Sleepy-bye Land. It is rarely prescribed as monotherapy for depression these days. It’s mostly an add-on antidepressant in case you have insomnia combined with your depression and/or anxiety, or prescribed as a sleep aid. If you respond well to SSRIs and you’re not sleeping or are otherwise agitated, trazodone might be a good addition to your cocktail to make sure you sleep. And sleep. And sleep. If you’re going for the combination of antipsychotic and antidepressant, you’ll probably want to avoid combining trazodone with Seroquel if you want to wake up any time this week. We’ve come across one person actually taking this combination and she had one hell of a time getting up every
afternoon morning. Actually she had a hell of a time getting up before one PM, so afternoon isn’t much of an exaggeration.
Given the nature of some of trazodone’s more…unusual side effects, it’s been evaluated for various sexual dysfunctions. The only one it’s half-decent for is SSRI-induced sexual dysfunction. So if you take an SSRI, still have some residual anxiety and insomnia, and can’t get it up with a forklift, trazodone might be worth a shot. It generally takes over 200mg a night before it does anything for your plumbing.
In case you’re wondering, this paper describes the surgery to correct priapism. It has pictures. Graphic pictures. They might be enough to take care of any hard-on you’ve had for more than four hours after taking Cialis or Viagra, or any you’d normally have for the next few days.
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It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.
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Physicians’ Desk Reference Edition 56 Maria Deutsch & Anu Gupta, Drug Information Specialists, et al. © 2002. Published by Medical Economics Company.
Instant Psychopharmacology 2nd Edition Ronald J. Diamond M.D. © 2002. Published by W.W. Norton
The Complete Guide to Psychiatric Drugs Edward Drummond, M.D. © 2000. Published by John Wiley & Sons, Inc.
Healing Anxiety & Depression Daniel G. Amen, M.D., and Lisa C. Routh, M.D. © 2003. Published by G.P. Putnam’s Sons.
Mosby’s 2004 Drug Consult David Nissen PharmD, Editor.© 2004. An imprint of Elsevier.1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.
2 It's probably responsible for the hangover you get the first few times you take trazodone. And you'd have to take a shitload of trazodone, probably a dangerously high amount, to get the ecstasy with a migraine effect.
3 Thank you! I'll be here at least 72 hours. Be sure to tip your content provider. And don't try the veal, it's cruelicious!
If you have any questions not answered here, please see the Crazymeds Desyrel discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)
|Last modified on Tuesday, 08 July, 2014 at 11:03:29 by JerodPoore||Page Author Jerod Poore||Date created|
|“Desyrel (trazodone): a Review for the Educated Consumer.” by Jerod Poore is copyright © Jerod Poore||Published online 2011/04/25|
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|Plain text:||Poore, Jerod. “Desyrel (trazodone): a Review for the Educated Consumer.” Crazymeds (crazymeds.us). ().|
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.
* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.