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> Desyrel



US brand name: Desyrel
Generic name: trazodone

Other Forms: orange flavored solution

Class: Antidepressants. Specifically a Serotonin Antagonist and Reuptake Inhibitor

1.  Other brand names & branded generic names1

  • Sideril
  • Trazalon
  • Trazonil
  • Azonz (Finland)
  • Beneficat (Argentina)
  • Bimaran (Argentina)
  • Deprax (Spain)
  • Depresil (Philippines)
  • Depyrel (Israel)
  • Desirel (Thailand)
  • Mesyrel (Taiwan)
  • Manegan (Argentina)
  • Molipaxin (United Kingdom; Ireland; South Africa)
  • Pragmarel (France)
  • Reslin (Japan)
  • Taxagon (Argentina)
  • Thombran (Germany)
  • Trazolan (Belgium; India; Netherlands)
  • Trazone (Indonesia; Portugal; Taiwan)
  • Trittico (Austria; Colombia; Greece; Hong Kong; Italy; Peru; Switzerland)
  • Torazodon (Japan)
  • Trittico (Israel)
  • Trazodil 100 (Israel)
  • レスリン (Japan)

2.  Trazodone’s FDA Approved Uses

Major depressive disorder, with or without anxiety.

3.  Trazodone’s Off-Label Uses

  • Panic/Anxiety
  • Sleep Disorders
  • Bipolar Depression
  • Insomnia
  • Chronic Fatigue
  • Sleep Problems
  • Fibromyalgia
  • Sleep Issues
  • Erectile Dysfunction, where it failed. But…
  • SSRI-induced sexual dysfunction. Overall the data are mixed, but it’s still worth a shot.
  • You’re getting sleepy
  • Arthritis
  • <Yawn> excuse me.
  • Lupus
  • sleepy
  • Irritable Bowel Syndrome
  • your eyes are getting heavy
  • Eating Disorders
  • Are you tired yet?

4.  Trazodone’s pros and cons

4.1  Pros

The antidepressant you need if you have the combination of insomnia combined with mild depression and/or anxiety.

4.2  Cons

You might just sleep a little too well.

5.  Trazodone’s Side Effects

5.1  Typical Side Effects

Sleepiness, headache, sleepiness, dizziness, sleepiness, nausea, sleepiness, dry mouth, sleepiness, blurry vision, sleepiness, sweating, sleepiness, insomnia or sleepiness, diarrhea or constipation, and did I mention you’ll be tired? Most everything but the sleepiness and, if you get the, dizziness and blurry vision, will go away within a week or two. The dizziness and blurry vision may take a little longer. If they last too long, talk to your doctor.

5.2  Not So Common Side Effects

Low blood pressure, weight gain. General cardiac weirdness, so trazodone shouldn’t be used if you have a history or family history of heart issues, at least, not without prior clearance from a cardiologist. Since it makes you sleep better, many people report vivid or unusual dreams. Like Seroquel, another medication prescribed for insomnia alone, there’s sometimes a nasty hangover the first few days after using trazodone. It usually goes away in a day or two.

5.3  Freaky Rare Side Effects

Priapism so bad that surgical intervention was required to get rid of the unending hard-on. Bob Dole shouldn’t have relied on Viagra to take on Bill Clinton, Bob Dole should have tried trazodone to go macho a macho with the president. Wait, there’s more. Not only can men get stuck that way, but women too, as it can cause clitoral priapism. And if that weren’t enough, persistent genital arousal disorder and spontaneous orgasms in an elderly postmenopausal woman.

6.  Interesting Stuff Your Doctor Probably Won’t Tell You about Trazodone

Trazodone is best taken with food, so take it after dinner, or dessert, to ensure a quality night’s rest.
The major metabolite of trazodone is meta-chlorophenylpiperazine (mCPP), one of the nigh-infinite number of drugs sold as “ecstasy” in the US in the 1990s. Why is beyond me, as it’s a hallucinogen that gives you a migraine2. Unless it was supposed to scare those party kids straight or something like that.



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7.  Trazodone’s Dosage and How to Take Trazodone

The initial dose is 150mg a night, taken after dinner or “a light snack.” But, really, start at just 50mg if you want to wake up the next morning. If you don’t respond after one week, increase it to 100mg. Unlike SSRIs, people respond to trazodone rather quickly, so you can work up to that 150mg dosage after two weeks, then wait a month before increasing the dosage. After that it’s an increase of 50mg a day every four days or so, dividing the dosage, until you reach the maximum of 400mg a day.

8.  How Long Trazodone Takes to Work

Like Remeron, two weeks for depression, one-to-two nights for sleep.

9.  How to Stop Taking trazodone

Your doctor should be recommending that you reduce your dosage by 50–100mg a day every 3–5 days if you need to stop taking trazodone.

10.  How Trazodone Works

Trazodone’s mechanism of action is similar to its chemical cousin nefazodone; they are Serotonin Antagonist and Reuptake Inhibitors (SARIs). Based upon the Communications Interference Hypothesis of psychiatric and neurological conditions (or brain cooties as we often call them), trazodone effectively raises the serotonin levels in your brain by letting your synapses soak in serotonin for longer than usual by slowing (inhibiting) the mechanism of serotonin transmission deeper into the neurons (reuptake). It also an antagonist - it blocks excessive amounts of a neurotransmitter - of serotonin, including any excessive serotonin created by its own reuptake inhibition, at the 5HT2A and 5HT2C receptors, excess norepinephrine at the alpha 1 noradrenergic receptors, and is an antihistamine approaching Zyprexa-level of potency. The first two account for its actions as an antidepressant. Being an 5HT2A and 5HT2C antagonist and literally 100 times more potent than Benadryl is why trazodone knocks you out until next Tuesday.

11.  Shelf life

5 years.

12.  Comments

Trazodone is the official antidepressant of Sleepy-bye Land. It is rarely prescribed as monotherapy for depression these days. It’s mostly an add-on antidepressant in case you have insomnia combined with your depression and/or anxiety, or prescribed as a sleep aid. If you respond well to SSRIs and you’re not sleeping or are otherwise agitated, trazodone might be a good addition to your cocktail to make sure you sleep. And sleep. And sleep. If you’re going for the combination of antipsychotic and antidepressant, you’ll probably want to avoid combining trazodone with Seroquel if you want to wake up any time this week. We’ve come across one person actually taking this combination and she had one hell of a time getting up every afternoon morning. Actually she had a hell of a time getting up before one PM, so afternoon isn’t much of an exaggeration.

Given the nature of some of trazodone’s more…unusual side effects, it’s been evaluated for various sexual dysfunctions. The only one it’s half-decent for is SSRI-induced sexual dysfunction. So if you take an SSRI, still have some residual anxiety and insomnia, and can’t get it up with a forklift, trazodone might be worth a shot. It generally takes over 200mg a night before it does anything for your plumbing.

In case you’re wondering, this paper describes the surgery to correct priapism. It has pictures. Graphic pictures. They might be enough to take care of any hard-on you’ve had for more than four hours after taking Cialis or Viagra, or any you’d normally have for the next few days.


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13.  Desyrel Ratings, Reviews, & Other Sites of Interest

Desyrel Ratings & Reviews Page.

13.1  Rate Desyrel

Give your overall impression of Desyrel on a scale of 0 to 5. Detailed ratings and reviews are available on the Desyrel Ratings & Reviews Page.

Get all critical about Desyrel

3.5 stars Rating 3.1 out of 5 from 74 criticisms.
Vote Distribution: 10 – 5 – 11 – 6 – 27 – 15


13.2  Rate this article

If you’re still feeling judgmental as well as just mental3, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.

Get all judgmental about the Desyrel (trazodone) Synopsis

4.5 stars Rating 4.2 out of 5 from 56 value judgments.
Vote Distribution: 2 – 1 – 1 – 4 – 20 – 28


13.3  Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, check for drug-drug interactions

Desyrel’s Full US Prescribing Information / PI Sheet

UK trazodone SPC

Drugs.com’s drug-drug and drug-food interaction checker

It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.



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13.4  Discussion board

If you have any questions not answered here, please see the Crazymeds Desyrel discussion board.


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14.  Bibliography

Physicians’ Desk Reference Edition 56 Maria Deutsch & Anu Gupta, Drug Information Specialists, et al. © 2002. Published by Medical Economics Company.

Instant Psychopharmacology 2nd Edition Ronald J. Diamond M.D. © 2002. Published by W.W. Norton

The Complete Guide to Psychiatric Drugs Edward Drummond, M.D. © 2000. Published by John Wiley & Sons, Inc.

Healing Anxiety & Depression Daniel G. Amen, M.D., and Lisa C. Routh, M.D. © 2003. Published by G.P. Putnam’s Sons.

Mosby’s 2004 Drug Consult David Nissen PharmD, Editor.© 2004. An imprint of Elsevier.


1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.

2 It's probably responsible for the hangover you get the first few times you take trazodone. And you'd have to take a shitload of trazodone, probably a dangerously high amount, to get the ecstasy with a migraine effect.

3 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!


If you have any questions not answered here, please see the Crazymeds Desyrel discussion board. I welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why I write these damn things. I’m frustrated enough as it is. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds.


Last modified on Tuesday, 25 March, 2014 at 18:01:27 by SomeMedCriticPage Author: JerodPooreDate created Monday, 25 April, 2011 at 12:58:34

Desyrel by JerodPoore is copyright © 2011 JerodPoore


Desyrel, and all other drug names on this page and use throughout the site, are a trademark of someone else. Look on the the PI sheet or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing.




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Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
All brand names of the drugs listed in this site are the trademarks of the companies named on the PI/SPC sheet associated with the medication, sometimes on the pages about the drugs, even though those companies may have been acquired by other companies who may or may not be listed in this site by the time you read this. Or the rights to the drug were sold to another company. And any or all of the companies involved may have changed their names.
Crazymeds is optimized for the browser you’re not using on the platform you wish you had. Between you and me, it all looks a lot cleaner using Safari or Chrome, although more than half of the visitors to this site use either Safari or Internet Explorer, so I’m doing my best to make things look nice for IE as well. I’m using Firefox and running Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
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‘Everything is true, nothing is permitted.’ - Jerod Poore


1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?
[begin rant] I rent a dedicated server for Crazymeds. It’s sitting on a rack somewhere in Southern California along with a bunch of other servers that other people have rented. The hardware is identical, but no two machines have exactly the same operating systems. I don’t even need to see what is on any of the others to know this. If somebody got their server at the exact same time, with the exact same features as I did, I’m confident that there would be noticeable differences in some aspects of the operating systems. So what does this mean? For one thing it means that no two computers in the same office of a single company have the same operating system, and the techs can spend hours figuring out what the fuck the problem could be based on that alone. It also means that application software like IP board that runs the forum here has to have so many fucking user-configurable bells and whistles that even when I read the manual I can’t find every setting, or every location that every flag needs to be set in order for a feature to run the way I want it to run. And in the real world it means you can get an MBA not only with an emphasis on resource planning, but with an emphasis on using SAP - a piece of software so complex there are now college programs on how to use it. You might think, “But don’t people learn how to use Photoshop or Adobe Illustrator in college?” Sure, in order to create stuff. And in a way you’re creating stuff with SAP. But do you get a Bachelor of Fine Arts degree with an emphasis on Photoshop?
Back in the Big Iron Age the operating systems were proprietary, and every computer that took up an entire room with a raised floor and HVAC system, and had less storage and processing power than an iPhone, had the same operating system as every other one, give or take a release level. But when a company bought application software like SAP, they also got the source code, which was usually documented and written in a way to make it easy to modify the hell out of it. Why? Because accounting principles may be the same the world over, and tax laws the same across each country and state, but no two companies have the same format for their reports, invoices, purchase orders and so forth. Standards existed and were universally ignored. If something went wrong it went wrong the same way for everyone, and was easy to track down. People didn’t need to take a college course to learn how to use a piece of software.
I’m not against the open source concept entirely. Back then all the programmers read the same magazines, so we all had the same homebrew utilities. We even had a forerunner of QR Code to scan the longer source code. Software vendors and computer manufacturers sponsored conventions so we could, among other things, swap recipes for such add-ons and utilities. While those things would make our lives easier, they had nothing to do with critical functions of the operating system. Unless badly implemented they would rarely cause key application software to crash and burn. Whereas today, with open source everything, who the hell knows what could be responsible some part of a system failing. [/end rant]

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